A crucial game for both sides, who have yet to register a point between them.
That stat will end on Sunday but three points for either team would go a long way towards securing Division 1 football again next year.
After losing out to a Vikki Wall inspired Meath last Monday, Mayo will hope that home advantage can swing this one in their favour.
Tyrone were well beaten by Armagh and have found the going tough to date after coming up from Division 2.
Both camps have made changes to their starting team for this one. For Mayo, Charlie Reilly Benson replaces Roisin Dyar in goal, with Niamh Mooney and Ciara Whyte named to start in place of Saoirse Delaney and Bree Hession.
On the Tyrone side, Grainne McKenna, Slaine McCarroll and Aoife Horisk get the nod to start, with Eimear Quinn, Sasha Byrne and Aoife Quinn dropping out.
The game is live on Midwest Radio on Sunday with thanks to Mulroy's Londis, Castlebar.
Mayo: C Reilly Benson; E Brennan, S Lally, D Caldwell (capt.); N Mooney, S El Massry, H Reape; E Murray, A Geraghty; L Wallace, A Gough, C Durkin; M Cannon, S Walsh, C Whyte.
Tyrone: A Coyle; J Lyons, J Barrett, G McKenna; C Canavan, M Corrigan, A Strain; A McHugh (capt.), M Mallon; S McCarroll, C Campbell, E McNamee; C McCaffrey, M Canavan, A Horisk.
